Research Journal of Pharmaceutical Dosage Form and Technology

Lakunde Sathish Kumar Jyothika ¹, Hindustan Abdul Ahad ¹, Chinthaginjala Haranath ¹, Shaik Kousar ¹, Hothur Dharani pal Gowd ¹, Sampathikota Halima Sadiya ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, IN

Abstract

The work is aimed at giving an overview of transdermal drug delivery systems (TDDS). In TDDS, an effective amount of a drug is applied across the skin at a controlled rate for the systemic effect. TDDS has become increasingly popular. In the last 30 years, it has been proposed as a potential new drug delivery system. These comprise more efficacious treatments and a reduced risk of adverse events; ensure safety; maintain steady-state plasma levels of drugs, while incapacitating the significant hitches of conventional oral dosage forms and parenteral preparations. It is best suited for diseases that require long-term, frequent dosing treatment. This review deals with drugs, polymers, and methods adopted in making TDDS in recent years by referring to reputed journals and textbooks. The authors succeed in gathering the information and the literature on the TDDS. The study concludes that the literature so far will help the researchers with a quick reference on the attempts so far made on TDDS.

Keywords

Drug, patches, stratum corneum, polymer, transdermal.

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Yarragunta Roja ¹, Hindustan Abdul Ahad ¹, Haranath Chinthaginjala ¹, Maninjeri Soumya ¹, Sana Muskan ¹, Nagaraju gari Kavyasree ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, IN

Abstract

The present article concentrates on the Buccal film. It is a buccoadhesive drug delivery system that enhances the safety, efficacy, and stability of active pharmaceutical ingredients. The buccal film is a novel technology due to its better option to optimize therapeutic efficacy. This drug delivery system is suitable for drugs that pass through high first-pass metabolism and are used for enhancing bioavailability. The buccal film can be formulated as a solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, or rolling method. Among them, the solvent casting method is mostly adopted. The buccal films are evaluated for mechanical properties viz., Organoleptic assessment, thickness, dryness, tack test, tensile strength, percent elongation, folding endurance, swelling assets, surface pH, contact angle, transparency, uniformity in drug content, disintegration, and in-vitro dissolution tests. The article gave a handful of literature on past work done on buccal films. This article helps with quick references to the earlier attempts so far made on buccal films.

Keywords

Buccal, Bioavailability, Film, Literature, Patient convenience.

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Hindustan Abdul Ahad ¹, Haranath Chinthaginjala ¹, Nagarajugari Kavyasree ¹, Jyothi Vinay Krishna ¹, Sushma Papireddypalli ¹, Kotlo Saijyoshna ¹

Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, IN

Abstract

The purpose of this study was to investigate previous research on fast-acting pills. Fast dissolving tablets (FDTs) have become a rapidly emerging field in the pharmaceutical business over the last ten years. For the administration of many medications, oral drug delivery remains the recommended method. Scientists have developed FDTs with increased patient compliance and convenience during insertion into the mouth because of recent technological advances. For simple administration of active pharmaceutical substances, these tablets crumble or dissolve in the mouth without the use of water. Because of the formulation's popularity and use, several FDT technologies have been developed. FDTs are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without the use of water or chewing. FDT shines in areas where pediatrics and geriatricshave trouble swallowing traditional tablets and capsules. FDT is a new drug delivery system that is intended for rapid dissolution and action, as well as treating acute illnesses with greater patient compliance. The authors gathered enough data from previous FDT trials. This review article can be used by researchers to quickly obtain latest literature on FDT.

Keywords

Disintegrating, Literature, Mouth dissolving, Past work, Polymers.

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